import wx

class MiniFrame(wx.MiniFrame):
    def __init__(self):
        wx.MiniFrame.__init__(self, None, -1, 'Mini Frame', 
                size=(300, 100))
        panel = wx.Panel(self, -1, size=(300, 100))
        button = wx.Button(panel, -1, "Close Me", pos=(15, 15))
        self.Bind(wx.EVT_BUTTON, self.OnCloseMe, button)
        self.Bind(wx.EVT_CLOSE, self.OnCloseWindow)

    def OnCloseMe(self, event):
        self.Close(True)

    def OnCloseWindow(self, event):
        self.Destroy()

if __name__ == '__main__':
    app = wx.PySimpleApp()
    MiniFrame().Show()
    app.MainLoop()