diff --git a/setup.h_vms b/setup.h_vms
index 56dccc58ac..4aa0e67498 100644
--- a/setup.h_vms
+++ b/setup.h_vms
@@ -918,6 +918,15 @@
 /* Define if you have ftime() */
 #define HAVE_FTIME
 
+/* Define if you have support for large (64 bit size) files */
+#undef HAVE_LARGEFILE_SUPPORT
+
+/* Required by HAVE_LARGEFILE_SUPPORT on some systems */
+#undef _FILE_OFFSET_BITS
+
+/* Ditto */
+#undef _LARGE_FILES
+
 /* Define if you have localtime() */
 #define HAVE_LOCALTIME