diff --git a/configure.ac b/configure.ac
index cc1b6e0c..91949944 100644
--- a/configure.ac
+++ b/configure.ac
@@ -70,13 +70,13 @@ AS_IF([test "x$EMSCRIPTEN" != "x"],[
   AC_MSG_WARN([compiling to javascript - asm implementations disabled])
 ])
 
-AS_CASE([$host], [x86_64-*-mingw* | x86_64-*-cygwin*], [enable_asm="no"])
+AS_CASE([$host], [x86_64-*-mingw*|x86_64-*-cygwin*|x86_64-*-msys], [enable_asm="no"])
 
 AC_ARG_ENABLE(pie,
 [AS_HELP_STRING(--disable-pie,Do not produce position independent executables)],
  enable_pie=$enableval, enable_pie="maybe")
 
-AS_CASE([$host_os], [mingw*], [enable_pie="no"])
+AS_CASE([$host_os], [mingw*|cygwin*|msys], [enable_pie="no"])
 
 AC_ARG_ENABLE(blocking-random,
 [AS_HELP_STRING(--enable-blocking-random,Use /dev/random instead of /dev/urandom)],
@@ -142,10 +142,12 @@ CPPFLAGS="$CPPFLAGS -D_FORTIFY_SOURCE=2"
 AX_CHECK_COMPILE_FLAG([-fvisibility=hidden],
   [CFLAGS="$CFLAGS -fvisibility=hidden"])
 
-AX_CHECK_COMPILE_FLAG([-fPIC], [
-  AX_CHECK_LINK_FLAG([-fPIC],
-    [CFLAGS="$CFLAGS -fPIC"]
-  )
+AS_CASE([$host_os], [cygwin*|mingw*|msys|pw32*|cegcc*], [ ], [
+  AX_CHECK_COMPILE_FLAG([-fPIC], [
+    AX_CHECK_LINK_FLAG([-fPIC],
+      [CFLAGS="$CFLAGS -fPIC"]
+    )
+  ])
 ])
 
 AS_IF([test "$enable_pie" != "no"],[
@@ -174,7 +176,7 @@ AC_ARG_ENABLE(soname-versions,
 )
 
 AS_CASE([$host_os],
-  [cygwin* | mingw* | pw32* | cegcc*], [
+  [cygwin*|mingw*|msys|pw32*|cegcc*], [
     AX_CHECK_LINK_FLAG([-Wl,--dynamicbase], [LDFLAGS="$LDFLAGS -Wl,--dynamicbase"])
     AX_CHECK_LINK_FLAG([-Wl,--nxcompat], [LDFLAGS="$LDFLAGS -Wl,--nxcompat"])
   ])
@@ -182,7 +184,7 @@ AS_CASE([$host_os],
 AS_IF([test "x$enable_ssp" != "xno"],[
 
 AS_CASE([$host_os],
-  [cygwin* | mingw* | pw32* | cegcc*], [ ],
+  [cygwin*|mingw*|msys|pw32*|cegcc*], [ ],
   [dragonfly*], [
     AX_CHECK_COMPILE_FLAG([-fstack-protector], [
       AX_CHECK_LINK_FLAG([-fstack-protector],